منابع مشابه
Rethinking origin licensing
Human cells that lack a subunit in their origin recognition complex are viable, which suggests the existence of alternative mechanisms to initiate DNA replication.
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Two recent and related social developments of note for libraries are an upsurge in cultural participation enabled by Web 2.0 media and calls in government policy for enhanced innovation through education. Ironically, these have occurred at the same time that increasingly stringent copyright laws have restricted access to cultural content. Concepts of governmentality are used here to examine the...
متن کاملRegulation of DNA Replication Origin Licensing
DNA replication is a fundamental biological process that serves to create two copies of the genetic material during each cell division. Complete and precise replication enables identical sets of genes to be faithfully delivered to daughter cells during each cell division. To achieve rapid duplication of the entire genome, eukaryotic cells initiate DNA replication at multiple locations on each c...
متن کاملMultiple kinases inhibit origin licensing and helicase
16 Meiotic cells undergo a single round of DNA replication followed by two rounds of 17 chromosome segregation (the meiotic divisions) to produce haploid gametes. Both DNA 18 replication and chromosome segregation are similarly regulated by CDK oscillations in mitotic 19 cells. Yet how these two events are uncoupled between the meiotic divisions is unclear. Using 20 Saccharomyces cerevisiae, we...
متن کاملRapid DNA replication origin licensing protects stem cell pluripotency
Complete and robust human genome duplication requires loading minichromosome maintenance (MCM) helicase complexes at many DNA replication origins, an essential process termed origin licensing. Licensing is restricted to G1 phase of the cell cycle, but G1 length varies widely among cell types. Using quantitative single-cell analyses, we found that pluripotent stem cells with naturally short G1 p...
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ژورنال
عنوان ژورنال: eLife
سال: 2017
ISSN: 2050-084X
DOI: 10.7554/elife.24052